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What Does It Take to Build a SMART on FHIR App for Epic Integration?

Michael Nikitin

CTO & Co-founder AIDA, CEO Itirra

Published on March 26, 2025

What Does It Take to Build a SMART on FHIR App for Epic Integration?

Building a SMART on FHIR application for Epic integration is a technical challenge that demands a deep understanding of both healthcare IT standards and the inner workings of Electronic Health Records (EHR) systems. These apps bridge the gap between healthcare providers, their data, and the tools they use to deliver quality care. When it comes to integrating with Epic—one of the most widely used EHR platforms in the world—the process can be especially complex, but it’s essential for modern healthcare organizations that want to improve their workflows, enhance clinical decision-making, and streamline patient care. In this blog, we’ll explore what it takes to create a SMART on FHIR app, the technologies involved, and how organizations like Itirra, a Washington state health tech lab, have been designing and deploying innovative solutions for over a decade for clients that serve the healthcare industry.

Understanding SMART on FHIR and Epic Integration

At the heart of building a SMART on FHIR app is the concept of FHIR (Fast Healthcare Interoperability Resources), which is a standard for exchanging healthcare information electronically. This framework allows different healthcare systems to communicate seamlessly, ensuring that data such as patient records, treatment plans, and diagnostic results can be shared easily across different platforms. SMART (Substitutable Medical Applications, Reusable Technologies) is a set of open standards built on top of FHIR to enable third-party applications to integrate securely with healthcare systems like Epic. Together, SMART on FHIR apps can function as standalone tools or be embedded directly within a healthcare organization’s existing EHR interface.

Epic, as a leading EHR platform, offers a robust API that supports integration with third-party applications. However, Epic’s complex data structures and stringent security requirements can make the process of building a SMART on FHIR app a challenge for developers. The FHIR API allows developers to access patient data, manage clinical workflows, and interact with the system through standardized web services. Developers need to understand how to authenticate users, manage access control, and ensure compliance with HIPAA (Health Insurance Portability and Accountability Act) regulations to create a secure and efficient integration.

The Development Process: Key Steps in Building a SMART on FHIR App

Building a SMART on FHIR app requires a methodical approach to ensure that both the technical and regulatory requirements are met. The development process typically begins with thorough planning and research into the specific needs of the healthcare organization. Understanding the clinical workflows and data requirements of an Epic integration is crucial for determining which features and functionalities should be included in the app. Developers must also evaluate how the app will interact with the Epic system and how data will be retrieved or updated in real time.

Once the planning phase is complete, developers begin by configuring the OAuth 2.0 authentication process to ensure secure access to patient data. OAuth 2.0 is a protocol that allows users to grant permissions to applications without sharing their credentials, which is critical for maintaining security in healthcare environments. After authentication is set up, developers work on building the core features of the app, including the ability to retrieve and display data from the Epic EHR system. These features may include patient demographics, medical history, medication lists, lab results, and more.

A key aspect of SMART on FHIR app development is ensuring that the application remains interoperable with other systems. This means adhering to standards like HL7 and IHE to ensure that data can flow seamlessly between Epic and any third-party tools or organizations involved. Moreover, developers must test the app rigorously to ensure it works as expected across different scenarios, from handling large datasets to maintaining performance in a live environment.

The Role of Itirra in Healthcare App Development 

For organizations that need custom EHR integrations, partnering with a specialized health tech lab can make a significant difference. Itirra, a health tech lab based in Washington state, has been at the forefront of designing, developing, and deploying bespoke EMR and EHR integration solutions for over a decade. Itirra’s expertise extends to developing SMART on FHIR applications that integrate seamlessly with Epic, allowing organizations that service the healthcare industry  like physician advisors, third-party medical consultants, and revenue cycle management companies to optimize their workflows and improve patient outcomes.

With a team of experienced health tech developers, Itirra has the knowledge and experience to navigate the complexities of building custom solutions tailored to the unique needs of organizations that service the healthcare industry. They understand the regulatory landscape, data security protocols, and industry standards required for successful Epic integrations. By working closely with organizations, Itirra ensures that each SMART on FHIR app they develop meets both clinical and business objectives while maintaining the highest standards of data integrity and privacy.

Challenges in Building SMART on FHIR Apps

Despite the advantages of SMART on FHIR apps, there are several challenges that developers face when integrating with Epic. One of the primary obstacles is ensuring that the app is compliant with a range of regulations, including HIPAA, HITECH (Health Information Technology for Economic and Clinical Health), and other state or federal laws that govern healthcare data. Compliance requires a deep understanding of encryption, user access management, and secure data transmission methods.

Another challenge lies in the ongoing support and maintenance of SMART on FHIR apps. Healthcare IT environments are constantly evolving, and the integration between Epic and third-party applications must be maintained over time to ensure compatibility with new features, bug fixes, and security updates. Developers must stay informed about changes to the Epic platform, the FHIR standard, and other relevant technologies to ensure the longevity and stability of the app.

The Future of SMART on FHIR Apps in Healthcare

As the healthcare industry continues to evolve toward a more patient-centered approach, the demand for interoperable solutions like SMART on FHIR apps is expected to grow. These apps not only improve the workflow of healthcare professionals but also enable patients to have more control over their health data. For instance, patients may be able to view their medical records, track their health data, or even interact with their providers through third-party apps integrated with Epic.

Looking ahead, the continued growth of FHIR-based applications will likely drive further innovation in the healthcare space. As new technologies like artificial intelligence, machine learning, and predictive analytics continue to make their way into healthcare, SMART on FHIR apps will play a pivotal role in enabling these technologies to work alongside existing EHR systems like Epic. The next generation of healthcare applications will be built with interoperability in mind, allowing for a more connected, efficient, and responsive healthcare ecosystem.

Conclusion

Building a SMART on FHIR app for Epic integration is no small feat, but with the right approach, tools, and expertise, it is entirely achievable. Organizations that wish to enhance their healthcare advisory and consultancy offerings and improve patient outcomes must consider the technical, regulatory, and practical aspects of such integrations. Working with an experienced partner like Itirra, which has a proven track record in EHR and EMR integration, can ensure that your custom SMART on FHIR app is secure, effective, and aligned with your specific needs. As the healthcare industry becomes increasingly digital and interconnected, the importance of well-designed integration solutions will only continue to grow, making it an exciting time for innovation in this space.

Contact Itirra today to learn more!